VirtualBox Ubuntu Guest Boots Up with “SMBus base address uninitialized” error

Error message on boot
piix4_smbus 0000:00:07.0: SMBus base address uninitialized - upgrade BIOS or use force_addr=0xaddr

Error is caused by Ubuntu trying to load the smbus module which doesn’t exists in VirtualBox guest. It doesn’t seem to affect the function of the guest machine, but it’s kind of disconcerting having that error every time the machine starts up.

See if the i2c_piix4 module is indeed loaded with the command
lsmod | grep i2c_piix4

Blacklist the loading of the i2c_piix4 module by adding it in
sudo nano /etc/modprobe.d/blacklist.conf
and add

blacklist i2c_piix4

at the end of the file.

Update the initramfs with the command
update-initramfs -u -k all

The prompt will return something like
update-initramfs: Generating /boot/initrd.img-2.6.35-22-server

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